Chris - Spam is Spam is Spam. 
In the next two years I see some serious problems with Spam. Molly the homemaker, who spents her days watching her 2.5 kids, gets tired of getting 100 emails and only two that are worth reading. I can see how it gets old. 
I pick up email from six different email addresses, some of which are not related to the industry. I also pick up "blanket staff email" from all of the Lightspeed Media sites. Who sends spam to 
support@tawneestone.com? 
Spam is kiilling email. Plain and simple.