I could never use those wrist rest pads. It just doesn't feel comfortable to me at all. I used to hold onto my mouse tight too for some reason. Most times, I never realized I was doing that. Once I learned to relax my hand, any soreness went away. I have my mouse at the edge of my desk too and pretty much rest my wrist on the edge of the desk. It seems to work for me because I seldom get any soreness in my wrist.
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